منابع مشابه
The Impression of Histone Modification and DNA Methylation in Gastric Cancer Development: Molecular Mechanism Approach
The epigenetic alterations like histone modifications , DNA methylation and others remarkable categories including nucleosome remodeling and RNA mediated targeting have been strongly investigated recently .In this way , beside the notable importance of DNA methylation ,the histone modifications are the most important issues in the tumorogenesis and cancer progression. Moreover...
متن کاملEpigenetic regulation by histone methylation and histone variants.
Epigenetics is the study of heritable changes in gene expression that are not mediated at the DNA sequence level. Molecular mechanisms that mediate epigenetic regulation include DNA methylation and chromatin/histone modifications. With the identification of key histone-modifying enzymes, the biological functions of many histone posttranslational modifications are now beginning to be elucidated....
متن کاملUnderstanding the relationship between DNA methylation and histone lysine methylation☆
DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has become clear that the DNA and histone lysine methylation systems are highly interrelated and rely mechanistically on each other for normal chromatin function in vivo. Here we examine some of the functional links between these systems, with a particular focus on several recent discoveries suggesting how lysine ...
متن کاملH1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation.
Epigenetic silencing in mammals involves DNA methylation and posttranslational modifications of core histones. Here we show that the H1 linker histone plays a key role in regulating both DNA methylation and histone H3 methylation at the H19 and Gtl2 loci in mouse ES cells. Some, but not all, murine H1 subtypes interact with DNA methyltransferases DNMT1 and DNMT3B. The interactions are direct an...
متن کاملHistone Deimination Antagonizes Arginine Methylation
Methylation of arginine residues within histone H3 has been linked to active transcription. This modification appears on the estrogen-regulated pS2 promoter when the CARM1 methyltransferase is recruited during transcriptional activation. Here we describe a process, deimination, that converts histone arginine to citrulline and antagonizes arginine methylation. We show that peptidyl arginine deim...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2016
ISSN: 1535-6108
DOI: 10.1016/j.ccell.2016.08.010